LACC1: A critical involvement in macrophage immunometabolism.

Abstract

Laccase domain-containing 1 (LACC1) protein is an enzyme highly expressed in inflammatory macrophages, and studies have shown that it has a key role in diseases such as inflammatory bowel disease, arthritis, and microbial infections. Therefore, in this review, we focus on LACC1-mediated catalysis. In detail, LACC1 converts l-CITrulline (l-CIT) to l-ORNithine (l-ORN) and isocyanic acid in mice and humans and acts as a bridge between proinflammatory nitric oxide synthase (NOS2) and polyamine immunometabolism, thus exerting anti-inflammatory and antibacterial effects. Considering the actions of LACC1, targeting LACC1 may be a potent therapeutic avenue for inflammation-related diseases and microbial infection diseases.

• Authors: Yaling Li, Zhixiong Wu, Xiaoli Tan, Liang Tang, Fan Ouyang
• Journal: Cell biology international (Cell Biol Int) Vol. 47 Issue 9 Pg. 1488-1490 (Sep 2023) ISSN: 1095-8355 [Electronic] England
• PMID: 37366569 (Publication Type: Journal Article, Review)
• Copyright: © 2023 International Federation of Cell Biology.

Chemical References

• Laccase
• Intracellular Signaling Peptides and Proteins
• Nitric Oxide
• LACC1 protein, human

Topics

• Humans
• Mice
• Animals
• Laccase (metabolism)
• Intracellular Signaling Peptides and Proteins (metabolism)
• Macrophages (metabolism)
• Arthritis (metabolism)
• Inflammatory Bowel Diseases (metabolism)
• Nitric Oxide (metabolism)