Miscarriage is the most common complication of pregnancy. The most common causes of early
miscarriage are
chromosomal abnormalities of the embryo, maternal endocrine abnormalities, organ malformations, and abnormal
immune factors. Late
miscarriages are mostly caused by factors such as cervical insufficiency. However, the causes of 50% of
miscarriages remain unknown. Recently, increasing attention has been given to the role of metabolic abnormalities in
miscarriage. In this review, we mainly discuss the roles of four major metabolic pathways (
glucose,
lipid, and
amino acid metabolism, and oxidation‒reduction balance) in
miscarriage and the metabolism-related genes that lead to metabolic disorders in
miscarriage. Depending on aetiology, the current treatments for
miscarriage include hormonal and immunological drugs, as well as surgery, while there are few
therapies for metabolism. Therefore, we also summarize the drugs for metabolism-related targets. The study of altered metabolism underlying
miscarriage not only helps us to understand the mechanisms involved in
miscarriage but also provides an important basis for clinical research on new
therapies.