Differential prediction of high-sensitivity cardiac troponin-I, but not N-terminal pro-brain natriuretic peptide, in different pitavastatin doses on cardiovascular events in stable coronary artery disease.

Abstract

BACKGROUND:

This study aimed to examine whether high-sensitivity cardiac troponin-I (hsTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP) could predict future major adverse cardiovascular events (MACE) in stable coronary artery disease (CAD) patients with high- or low-dose of pitavastatin.

METHODS:

This was a case-cohort analysis of the REAL-CAD study, a randomized trial of high- or low-dose (4 or 1 mg/day) pitavastatin therapy in patients with stable CAD. We examined the MACE risk according to the quartile of hsTnI and NT-proBNP at baseline.

RESULTS:

A total of 1336 and 1396 patients including 582 MACE cases were randomly examined into the hsTnI and NT-proBNP cohort, respectively. Both higher levels of hsTnI and NT-proBNP at baseline were significantly associated with increased risk of MACE (p < 0.001, respectively). When separately analyzed in statin dose, the higher marker levels were significantly associated with higher MACE risk in all cohorts (p < 0.001 in all cohorts). After multivariable adjustment, hsTnI levels were significantly associated with MACE risk in low-dose statin group (HR 2.54, p = 0.0001); however, in high-dose pitavastatin therapy, a significant association was diminished in MACE risk among the quartiles of baseline hsTnI levels (p = 0.154). Conversely in the NT-proBNP cohort, the association between NT-proBNP levels and MACE risk was constantly observed regardless of pitavastatin dose even after multivariable adjustment (both p < 0.0001).

CONCLUSIONS:

Patients with high hsTnI levels had high risk of MACE in low-dose statin group, but not in high-dose, suggesting that high-dose statin treatment might decrease MACE risk in stable CAD patients with high hsTnI levels.

• Authors: Yoshiaki Mitsutake, Junnichi Ishii, Yoshihiro Fukumoto, Sohei Ito, Kosuke Kashiwabara, Kouhei Uemura, Yutaka Matsuyama, Yoichi Sugiyama, Yukio Ozaki, Satoshi Iimuro, Hiroshi Iwata, Ichiro Sakuma, Yoshihisa Nakagawa, Kiyoshi Hibi, Takafumi Hiro, Seiji Hokimoto, Katsumi Miyauchi, Hiroyuki Daida, Hiroaki Shimokawa, Yasushi Saito, Takeshi Kimura, Masunori Matsuzaki, Ryozo Nagai
• Journal: International journal of cardiology (Int J Cardiol) Vol. 387 Pg. 131138 (09 15 2023) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 37355235 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Natriuretic Peptide, Brain
• Peptide Fragments
• pitavastatin
• pro-brain natriuretic peptide (1-76)
• Troponin I

Topics

• Humans
• Biomarkers
• Coronary Artery Disease (diagnosis, drug therapy)
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Natriuretic Peptide, Brain
• Peptide Fragments
• Prognosis
• Troponin I