Abstract | AIMS: METHODS: The clinical data of patients with HBV-HCC who received either TACE+AC or TACE+A treatment were retrospectively analyzed. Overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs) were compared between the two groups. Multivariate Cox proportional hazards model regression analysis was used to identify the independent prognostic factors of OS. RESULTS: Between March 2019 to January 2022, 76 patients were assigned to the TACE+AC group (n = 37) and the TACE+A group (n=39). The median OS and PFS in the TACE+AC group were significantly longer than those in the TACE+A group (OS, 15.4 vs. 11.3 months; p=0.008; PFS, 7.4 vs. 5.1 months; p=0.001) and the ORR and DCR in the TACE + AC group were significantly greater than those in the TACE+A group (ORR, 43.2% vs. 20.5%; p=0.033; DCR, 67.6% vs. 43.6%; p=0.036). There was no significant difference in the incidence of grade ≥3 AEs between the two groups (p=0.483). Multivariate regression analysis identified the treatment modalities, AFP level, and extrahepatic metastasis as independent prognostic factors (p<0.05). CONCLUSION: TACE+AC significantly improved the clinical outcomes of patients with HBV-HCC and elicited relatively controllable AEs.
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Authors | Haonan Liu, Qianqian Yu, Ting Gu, Pengfei Qu, Xiao Ma, Shuang Zhou, Tong Lu, Di Pan, Zhengxiang Han |
Journal | Journal of gastrointestinal and liver diseases : JGLD
(J Gastrointestin Liver Dis)
Vol. 32
Issue 2
Pg. 182-189
(06 22 2023)
ISSN: 1842-1121 [Electronic] Romania |
PMID | 37345608
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Humans
- Carcinoma, Hepatocellular
(pathology)
- Liver Neoplasms
(pathology)
- Hepatitis B virus
- Retrospective Studies
- Chemoembolization, Therapeutic
(adverse effects)
- Combined Modality Therapy
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