Blending Low-Frequency Vibrations and Push-Pull Effects Affords Superior Photoacoustic Imaging Agents.

Abstract

Photoacoustic imaging (PAI), a state-of-the-art noninvasive in vivo imaging technique, has been widely used in clinical disease diagnosis. However, the design of high-performance PAI agents with three key characteristics, i.e., near-infrared (NIR) absorption (λabs >800 nm), intense PA signals, and excellent photostability, remains a challenging goal. Herein, we present a facile but effective approach for engineering PAI agents by amplifying intramolecular low-frequency vibrations and enhancing the push-pull effect. As a demonstration of this blended approach, we constructed a PAI agent (BDP1-NEt2 ) based on the boron-dipyrromethene (BODIPY) scaffold. Compared with indocyanine green (ICG, an FDA-approved organic dye widely utilized in PAI studies; λabs =788 nm), BDP1-NEt2 exhibited a UV/Vis-NIR spectrum peaked at 825 nm, superior in vivo PA signal intensity and outstanding stability to offer improved tumor diagnostics. We believe this work provides a promising strategy to develop the next generation of PAI agents.

• Authors: Le Yu, Syed Ali Abbas Abedi, Jeongjin Lee, Yunjie Xu, Subin Son, Weijie Chi, Mingle Li, Xiaogang Liu, Jae Hyung Park, Jong Seung Kim
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 62 Issue 32 Pg. e202307797 (08 07 2023) ISSN: 1521-3773 [Electronic] Germany
• PMID: 37336786 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2023 Wiley-VCH GmbH.

Chemical References

• Indocyanine Green
• Coloring Agents

Topics

• Photoacoustic Techniques (methods)
• Vibration
• Indocyanine Green
• Coloring Agents
• Diagnostic Imaging