Abstract | BACKGROUND: MATERIAL AND METHODS: In this study, we retrospectively analyzed the efficacy and RCCEP occurrence of camrelizumab in 58 patients with R/M HNSCC in the Shanghai Ninth People's Hospital affiliated to Shanghai JiaoTong University School of Medicine between January 2019 and June 2022. Kaplan-Meier analysis was used to assess the correlation between the occurrence of RCCEP and the survival of enrolled patients, and COX multifactor analysis was adopted to evaluate associated factors that affected the efficacy of camrelizumab immunotherapy. RESULTS: A significant correlation between the incidence of RCCEP and a higher objective response rate was observed in this study (p=0.008). The occurrence of RCCEP was associated with better median overall survival (17.0 months vs. 8.7 months, p<0.0001, HR=5.944, 95% CI:2.097-16.84) and better median progression-free survival (15.1 months vs. 4.0 months, p<0.0001, HR=4.329,95% CI:1.683-11.13). In COX multifactor analysis, RCCEP occurrence was also an independent prognostic factor affecting OS and PFS in patients with R/M HNSCC. CONCLUSIONS: The occurrence of RCCEP can show a better prognosis, it could be used as a clinical biomarker to predict the efficacy of camrelizumab treatment.
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Authors | Q Ding, Y Liu, H Ju, H Song, Y Xiao, X Liu, G Ren, D Wei |
Journal | Medicina oral, patologia oral y cirugia bucal
(Med Oral Patol Oral Cir Bucal)
Vol. 28
Issue 6
Pg. e525-e529
(Nov 01 2023)
ISSN: 1698-6946 [Electronic] Spain |
PMID | 37330963
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Humans
- Cell Proliferation
- China
- Head and Neck Neoplasms
(drug therapy, epidemiology)
- Neoplasm Recurrence, Local
(drug therapy)
- Retrospective Studies
- Squamous Cell Carcinoma of Head and Neck
(drug therapy, epidemiology)
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