Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics.

Abstract

Loss of a kidney results in compensatory growth of the remaining kidney, a phenomenon of considerable clinical importance. However, the mechanisms involved are largely unknown. Here, we use a multi-omic approach in a unilateral nephrectomy model in male mice to identify signaling processes associated with renal compensatory hypertrophy, demonstrating that the lipid-activated transcription factor peroxisome proliferator-activated receptor alpha (PPARα) is an important determinant of proximal tubule cell size and is a likely mediator of compensatory proximal tubule hypertrophy.

• Authors: Hiroaki Kikuchi, Chung-Lin Chou, Chin-Rang Yang, Lihe Chen, Hyun Jun Jung, Euijung Park, Kavee Limbutara, Benjamin Carter, Zhi-Hong Yang, Julia F Kun, Alan T Remaley, Mark A Knepper
• Journal: Nature communications (Nat Commun) Vol. 14 Issue 1 Pg. 3481 (06 16 2023) ISSN: 2041-1723 [Electronic] England
• PMID: 37328470 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)
• Copyright: © 2023. The Author(s).

Topics

• Male
• Mice
• Animals
• Multiomics
• Kidney
• Nephrectomy
• Hypertrophy
• Kidney Tubules, Proximal