Abstract |
Developing an effective dressing against bacterial infection and synchronously addressing wound complications, such as bleeding, long-term inflammation, and reinfection, are highly desirable in clinical practice. In this work, a second near-infrared (NIR-II) responsive nanohybrid consisting of imipenem encapsulated liposome with gold-shell and lipopolysaccharide (LPS)-targeting aptamer, namely ILGA, is constructed for bacteria elimination. Benefiting from the delicate structure, ILGA exhibits strong affinity and a reliable photothermal/ antibiotic therapeutic effect toward multidrug-resistant Pseudomonas aeruginosa (MDR-PA). Furthermore, by incorporating ILGA with a thermosensitive hydrogel poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolic acid) (PLGA- PEG-PLGA), a sprayable dressing ILGA@Gel was prepared, which enables a quick on-demand gelation (10 s) for wound hemostasis and offers excellent photothermal/ antibiotic efficacy to sterilize the infected wound. Additionally, ILGA@Gel provides satisfactory wound-healing environments by reeducating wound-associated macrophages for inflammation alleviation and forming a gel layer to block exogenous bacterial reinfection. This biomimetic hydrogel reveals excellent bacteria eradication and wound recovery effectiveness, demonstrating its promising potential for managing complicated infected wounds.
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Authors | Weilun Pan, Bodeng Wu, Chengtao Nie, Tingting Luo, Zhenli Song, Jie Lv, Yong Tan, Chunchen Liu, Mingzhen Zhong, Tong Liao, Zhenxun Wang, Guanghui Yi, Limin Zhang, Xiaoliu Liu, Bo Li, Jinxiang Chen, Lei Zheng |
Journal | ACS nano
(ACS Nano)
Vol. 17
Issue 12
Pg. 11253-11267
(06 27 2023)
ISSN: 1936-086X [Electronic] United States |
PMID | 37314783
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hydrogels
- poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolic acid)
- Anti-Bacterial Agents
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Topics |
- Humans
- Hydrogels
(pharmacology, chemistry)
- Reinfection
- Anti-Bacterial Agents
(pharmacology, chemistry)
- Bandages
- Bacteria
- Inflammation
- Wound Infection
(drug therapy)
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