Objective: To analyze the status of
statins use and
low-density lipoprotein cholesterol (
LDL-C) management in patients with
atrial fibrillation (AF) and very high/high risk of atherosclerotic
cardiovascular disease (ASCVD) from Chinese
Atrial Fibrillation Registry (CAFR). Methods: A total of 9 119 patients with AF were recruited in CAFR between January 1, 2015 to December 31, 2018, patients at very high and high risk of ASCVD were included in this study. Demographics, medical history, cardiovascular risk factors, and laboratory test results were collected. In patients with very high-risk, a threshold of 1.8 mmol/L was used as
LDL-C management target and in patients with high risk, a threshold of 2.6 mmol/L was used as
LDL-C management target.
Statins use and
LDL-C compliance rate were analyzed, multiple regression analysis was performed to explore the influencing factors of
statins use. Results: 3 833 patients were selected (1 912 (21.0%) in very high risk of ASCVD group and 1 921 (21.1%) in high risk of ASCVD group). The proportion of patients with very high and high risk of ASCVD taking
statins was 60.2% (1 151/1 912) and 38.6% (741/1 921), respectively. Attainment rate of
LDL-C management target in patients with very high and high risk were 26.7% (511/1 912) and 36.4% (700/1 921), respectively. Conclusion: The proportion of
statins use and attainment rate of
LDL-C management target are low in AF patients with very high and high risk of ASCVD in this cohort. The comprehensive management in AF patients should be further strengthened, especially the primary prevention of
cardiovascular disease in AF patients with very high and high risk of ASCVD.