Baseline neuropsychiatric symptoms and psychotropic medication use midway through data collection of the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort.

Abstract

INTRODUCTION:

We examined neuropsychiatric symptoms (NPS) and psychotropic medication use in a large sample of individuals with early-onset Alzheimer's disease (EOAD; onset 40-64 years) at the midway point of data collection for the Longitudinal Early-onset Alzheimer's Disease Study (LEADS).

METHODS:

Baseline NPS (Neuropsychiatric Inventory - Questionnaire; Geriatric Depression Scale) and psychotropic medication use from 282 participants enrolled in LEADS were compared across diagnostic groups - amyloid-positive EOAD (n = 212) and amyloid negative early-onset non-Alzheimer's disease (EOnonAD; n = 70).

RESULTS:

Affective behaviors were the most common NPS in EOAD at similar frequencies to EOnonAD. Tension and impulse control behaviors were more common in EOnonAD. A minority of participants were using psychotropic medications, and use was higher in EOnonAD.

DISCUSSION:

Overall NPS burden and psychotropic medication use were higher in EOnonAD than EOAD participants. Future research will investigate moderators and etiological drivers of NPS, and NPS differences in EOAD versus late-onset AD.

• Authors: Angelina J Polsinelli, Ryan J Wonderlin, Dustin B Hammers, Alex Pena Garcia, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Laurel Beckett, Sujuan Gao, Sophia Wang, Kala Kirby, Paige E Logan, Paul Aisen, Jeffrey L Dage, Tatiana Foroud, Percy Griffin, Leonardo Iaccarino, Joel H Kramer, Robert Koeppe, Walter A Kukull, Renaud La Joie, Nidhi S Mundada, Melissa E Murray, Kelly Nudelman, David N Soleimani-Meigooni, Malia Rumbaugh, Arthur W Toga, Alexandra Touroutoglou, Prashanthi Vemuri, Alireza Atri, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Lawrence S Honig, David T Jones, Joseph Masdeu, Mario F Mendez, Kyle Womack, Erik Musiek, Chiadi U Onyike, Meghan Riddle, Emily Rogalski, Steven Salloway, Sharon J Sha, Raymond S Turner, Thomas S Wingo, David A Wolk, Maria C Carrillo, Bradford C Dickerson, Gil D Rabinovici, Liana G Apostolova, LEADS Consortium
• Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association (Alzheimers Dement) Vol. 19 Suppl 9 Pg. S42-S48 (11 2023) ISSN: 1552-5279 [Electronic] United States
• PMID: 37296082 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

Topics

• Humans
• Aged
• Alzheimer Disease (drug therapy, psychology)
• Longitudinal Studies
• Data Collection