Stimuli-responsive nanocarrier delivery systems for Pt-based antitumor complexes: a review.

Abstract

Platinum-based anticancer drugs play a crucial role in the clinical treatment of various cancers. However, the application of platinum-based drugs is heavily restricted by their severe toxicity and drug resistance/cross resistance. Various drug delivery systems have been developed to overcome these limitations of platinum-based chemotherapy. Stimuli-responsive nanocarrier drug delivery systems as one of the most promising strategies attract more attention. And huge progress in stimuli-responsive nanocarrier delivery systems of platinum-based drugs has been made. In these systems, a variety of triggers including endogenous and extracorporeal stimuli have been employed. Endogenous stimuli mainly include pH-, thermo-, enzyme- and redox-responsive nanocarriers. Extracorporeal stimuli include light-, magnetic field- and ultrasound responsive nanocarriers. In this review, we present the recent advances in stimuli-responsive drug delivery systems with different nanocarriers for improving the efficacy and reducing the side effects of platinum-based anticancer drugs.

• Authors: Tianshuai Wang, Chen Wu, Yanggen Hu, Yan Zhang, Junkai Ma
• Journal: RSC advances (RSC Adv) Vol. 13 Issue 24 Pg. 16488-16511 (May 30 2023) ISSN: 2046-2069 [Electronic] England
• PMID: 37274408 (Publication Type: Journal Article, Review)
• Copyright: This journal is © The Royal Society of Chemistry.