Abstract | INTRODUCTION: OBJECTIVE: METHODS: The search was executed in PubMed, Embase, OVID, the Cochrane Library and ClinicalTrials.gov for relevant studies. The network meta-analysis was performed by using Stata 16.0, and the outcome measures of the analysis were symptom score reductions of patients. Relative risks with 95% Confidence Intervals were used in the network meta-analysis to compare the clinical effect of treatments involved, and Surface Under the Cumulative Ranking Curves (SUCRAs) were also calculated to rank the treatments' efficacy. RESULTS: 18 eligible randomized controlled studies, involving a total of 9419 participants, were included in this meta-analysis. All the antihistamine treatments outperformed placebo in total symptom score reduction and each individual symptom score reduction. According to the results of SUCRA, rupatadine 20 mg and rupatadine 10 mg were ranked relatively high in reductions of total symptom score (SUCRA: 99.7%, 76.3%), nasal congestion score (SUCRA: 96.4%, 76.4%), rhinorrhea score (SUCRA: 96.6%, 74.6%) and ocular symptom score (SUCRA: 97.2%, 88.8%); rupatadine 20 mg and levocetirizine 5 mg were ranked relatively high in reductions of nasal itching score (SUCRA: 84.8%, 83.4%) and sneezing score (SUCRA: 87.3%, 95.4%); loratadine 10 mg was ranked the lowest in each symptom score reduction besides placebo. CONCLUSION:
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Authors | Dongdong Hong, Juanling Weng, Meiting Ye, Yuanxian Liu |
Journal | Brazilian journal of otorhinolaryngology
(Braz J Otorhinolaryngol)
2023 Jul-Aug
Vol. 89
Issue 4
Pg. 101272
ISSN: 1808-8686 [Electronic] Brazil |
PMID | 37271114
(Publication Type: Meta-Analysis, Systematic Review, Journal Article, Review)
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Copyright | Copyright © 2023 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier España, S.L.U. All rights reserved. |
Chemical References |
- rupatadine
- Loratadine
- Histamine H1 Antagonists
- Histamine Antagonists
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Topics |
- Humans
- Loratadine
(therapeutic use)
- Network Meta-Analysis
- Randomized Controlled Trials as Topic
- Histamine H1 Antagonists
(therapeutic use)
- Histamine Antagonists
(therapeutic use)
- Rhinitis, Allergic
(drug therapy)
- Treatment Outcome
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