Abstract | BACKGROUND: METHODS: A comprehensive search of databases, including the Cochrane Library, PubMed, Embase, and Web of Science, was conducted from the inception of the knowledge base up until January 2023. The metafor-package was employed to compare ototoxicity rates in individuals receiving radiotherapy. Two independent assessors extracted data and analyzed targets using a random-effects model. RESULTS: Out of the 28 randomized controlled trials (RCTs) included in the analysis, 25 were prospective RCTs. Subgroup analysis revealed that mean cochlear radiation dose, primary tumor location, radiotherapy modality, and patient age significantly influenced total hearing impairment. Intensity-modulated radiotherapy was associated with less ototoxicity than 2D conventional radiotherapy (OR, 0.53; 95% CI, 0.47-0.60; P = 0.73; I2 = 0%). Stereotactic radiotherapy appeared to be a superior option for hearing preservation compared to radiosurgery (OR, 1.44; 95% CI, 1.00-2.07; P = 0.69; I2 = 0%). Children demonstrated a higher risk of hearing impairment than adults. More than 50% of patients with vestibular neuroadenoma experienced hearing impairment following radiation therapy. A strong association was observed between the average cochlear radiation dose and hearing impairment. Increased cochlear radiation doses may result in a heightened risk of hearing impairment. CONCLUSION:
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Authors | Yan Huang, Hong Zhou, Fenglan An, Aimei Zhao, Jian Wu, Meihua Wang, Judong Luo |
Journal | Radiation oncology (London, England)
(Radiat Oncol)
Vol. 18
Issue 1
Pg. 95
(Jun 03 2023)
ISSN: 1748-717X [Electronic] England |
PMID | 37270526
(Publication Type: Journal Article, Systematic Review)
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Copyright | © 2023. The Author(s). |
Topics |
- Adult
- Child
- Humans
- Hearing
(radiation effects)
- Hearing Loss
(etiology)
- Ototoxicity
(complications)
- Radiosurgery
(adverse effects)
- Radiotherapy
(adverse effects)
- Radiotherapy, Intensity-Modulated
(adverse effects)
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