Abstract | INTRODUCTION: AREAS COVERED: This review appraised the evidence from clinical studies on various pharmacological and non-pharmacological therapies for sleep disturbances in AD patients and proposed an algorithm to manage sleep disturbances in this population of patients. EXPERT OPINION: Non-pharmacological interventions are generally preferred as the first-line approach to improve sleep-related symptoms in AD due to their favorable safety profile. However, when non-pharmacological interventions alone are insufficient, a range of pharmacological agents can be considered. Trazodone and melatonin are commonly used as adjunctive therapies, while Z-drugs including zopiclone and zolpidem are specifically employed to treat insomnia in patients with late-onset AD. Furthermore, a newer class of agents known as dual orexin receptor antagonists has emerged and gained approval for improving sleep onset and maintenance in AD patients.
|
Authors | Binish Javed, Amaan Javed, Chia Siang Kow, Syed Shahzad Hasan |
Journal | Expert review of neurotherapeutics
(Expert Rev Neurother)
Vol. 23
Issue 6
Pg. 501-514
(06 2023)
ISSN: 1744-8360 [Electronic] England |
PMID | 37267149
(Publication Type: Journal Article, Review)
|
Topics |
- Humans
- Alzheimer Disease
(complications, therapy)
- Sleep
- Sleep Wake Disorders
(etiology, therapy)
|