Abstract | BACKGROUND: METHODS: Our study cohort included 3978 patients from 85 institutions. Those who underwent NAC or NACRT followed by surgery for esophageal squamous cell carcinoma (ESCC) were eligible for inclusion. We used the inverse probability of treatment weighting (IPTW) method to compare the outcomes between NAC and NACRT. RESULTS: Among the 3978 patients, 3777 (94.9%) received NAC and 201 (5.1%) received NACRT. After IPTW adjustment, the NACRT group had more patients with pathologically downstaged diseases and significantly better pathological response compared with the NAC group (p < 0.001); however, 5-year overall survival (OS), recurrence-free survival (RFS), and regional recurrence-specific survival (RRSS) were comparable between the groups. Subgroup analysis stratifying patients according to cT category showed that among cT1-2 patients, those in the NACRT group had significantly longer 5-year OS, RFS, and RRSS than those in the NAC group (P = 0.024, < 0.001, and 0.020, respectively). In contrast, no significant differences were observed among cT3-4a patients. The competing risks regression model showed comparable subdistribution hazard ratios for 10-year cancerous and noncancerous deaths between the NAC and NACRT groups. CONCLUSIONS: Compared with NAC, NACRT for ESCC did not promote better survival despite better therapeutic effects and did not increase noncancerous deaths.
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Authors | Akihiko Okamura, Masayuki Watanabe, Jun Okui, Satoru Matsuda, Ryo Takemura, Hirofumi Kawakubo, Hiroya Takeuchi, Manabu Muto, Yoshihiro Kakeji, Yuko Kitagawa, Yuichiro Doki |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 30
Issue 9
Pg. 5885-5894
(Sep 2023)
ISSN: 1534-4681 [Electronic] United States |
PMID | 37264286
(Publication Type: Journal Article)
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Copyright | © 2023. Society of Surgical Oncology. |
Topics |
- Humans
- Esophageal Squamous Cell Carcinoma
(drug therapy)
- Neoadjuvant Therapy
- Esophageal Neoplasms
(pathology)
- East Asian People
- Chemoradiotherapy
- Retrospective Studies
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