Abstract | BACKGROUND: SCOPE AND APPROACH: Dietary sources of AA and biosynthesis of eicosanoids from AA through different metabolic pathways are summarized. The bioactivities of eicosanoids and their potential molecular mechanisms on inflammation and cancer are revealed. Additionally, current challenges and limitations in eicosanoid research on inflammation-related cancer are discussed. KEY FINDINGS AND CONCLUSIONS:
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Authors | Haixia Yang, Eva Rothenberger, Tong Zhao, Wendong Fan, Abigail Kelly, Ahmed Attaya, Daidi Fan, Dipak Panigrahy, Jianjun Deng |
Journal | Pharmacology & therapeutics
(Pharmacol Ther)
Vol. 248
Pg. 108455
(08 2023)
ISSN: 1879-016X [Electronic] England |
PMID | 37257760
(Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2023 Elsevier Inc. All rights reserved. |
Chemical References |
- Eicosanoids
- Arachidonic Acid
- Leukotrienes
- Cyclooxygenase 2
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Topics |
- Humans
- Eicosanoids
(metabolism)
- Arachidonic Acid
(metabolism)
- Neoplasms
(metabolism)
- Leukotrienes
- Inflammation
(metabolism)
- Cyclooxygenase 2
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