The association between chronic
inflammation and depression, anxiety,
anhedonia, and quality of life (QoL) has been recently emphasized. However, the pathophysiology of this relationship remains unsolved. This study aims to assess the dependence between vascular
inflammation represented by
eicosanoid concentration and quality of life in patients with
peripheral arterial disease (PAD). A total of 175 patients undergoing endovascular treatment due to lower limbs
ischemia were covered with eight years of observation after the
endovascular procedure, including ankle-brachial index (ABI), color Doppler ultrasound examination, urinary
leukotriene E4 (
LTE4),
thromboxane B2 (TXB2) and
5-Hydroxyeicosatetraenoic acid (5-HETE) measurement and quality-of-life assessment with VascuQol-6. The baseline concentrations of
LTE4 and TXB2 reversely correlated with preoperative VascuQol-6 and were predictive of the postoperative values of VascuQol-6 at each follow-up. At every follow-up timepoint, the results of VascuQol-6 reflected the
LTE4 and TXB2 concentrations. Higher concentrations of
LTE4 and TXB2 were correlated with lower life quality during the next follow-up meeting. Changes in VascuQol-6 at eight years vs. preoperative values were reversely related to the preoperative concentrations of
LTE4 and TXB2. This is the first study to confirm that changes in life quality in PAD patients undergoing endovascular treatment are highly dependent on
eicosanoid-based vascular
inflammation.