Abstract | BACKGROUND: METHODS: A systematic search of studies published between 2002 and 2022 on MEDLINE, PubMed, Google Scholar, and the Cochrane Library was performed. Studies that included adults with emergence agitation and/or delirium and reported at least one of the following outcomes: mortality, postoperative delirium, length of post- anesthesia care unit stay, or length of hospital stay were included. The internal validity, risk of bias, and certainty of the evidence were assessed. RESULTS: A total of 16,028 patients from 21 prospective observational studies and one case-control retrospective study were included in this meta-analysis. The occurrence rate of ePND was 13% (data excluding the case-control study). The mortality rate was 2.4% in patients with ePND vs. 1.2% in the normal emergence group (risk ratio [RR]: 2.6, P = 0.01, very low quality of evidence). Postoperative delirium occurred in 29% of patients with ePND and 4.5% of patients with normal emergence (RR: 9.5, P < 0.001, I2 = 93%). Patients with ePND had a prolonged length of post- anesthesia care unit stay (P = 0.004) and length of hospital stay (P < 0.001). CONCLUSIONS: This meta-analysis suggests that ePND are associated with twice the risk of mortality and a 9-fold increased risk of postoperative delirium.
|
Authors | Valery V Likhvantsev, Giovanni Landoni, Levan B Berikashvili, Nadezhda V Ermokhina, Mikhail Ya Yadgarov, Yuki Kotani, Kristina K Kadantseva, Dmitry M Makarevich, Andrey V Grechko |
Journal | Korean journal of anesthesiology
(Korean J Anesthesiol)
Vol. 76
Issue 5
Pg. 490-500
(10 2023)
ISSN: 2005-7563 [Electronic] Korea (South) |
PMID | 37232073
(Publication Type: Meta-Analysis, Journal Article)
|
Topics |
- Adult
- Humans
- Emergence Delirium
(epidemiology, etiology)
- Retrospective Studies
- Case-Control Studies
- Anesthesia
- Prospective Studies
- Observational Studies as Topic
|