Real-Time Identification of Nodal Metastases With 99m Tc-Prostate-Specific Membrane Antigen-Based Radioguidance and Indocyanine Green Fluorescence Imaging in Primary Prostate Cancer Surgery-On the Road to Hybrid Image-Guided Surgery.

Abstract

ABSTRACT:

Recent developments in image-guided prostate cancer surgery focus on extending prostate-specific membrane antigen-directed radioguidance with optical tumor detection using fluorescence, as radio- and fluorescence signals complement each other with in-depth detection and real-time visualization, respectively. As a step in this direction, we report here the integration of indocyanine green fluorescence imaging into a 99m Tc-prostate-specific membrane antigen-targeted radioguided surgery workflow.

• Authors: Hilda A de Barros, Matthias N van Oosterom, Fijs W B van Leeuwen, Henk G van der Poel, Pim J van Leeuwen
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 48 Issue 8 Pg. 697-698 (Aug 01 2023) ISSN: 1536-0229 [Electronic] United States
• PMID: 37220246 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Indocyanine Green

Topics

• Male
• Humans
• Indocyanine Green
• Prostate (pathology)
• Surgery, Computer-Assisted (methods)
• Prostatic Neoplasms (diagnostic imaging, surgery, pathology)
• Optical Imaging (methods)