[Uterin adenosarcoma: French Guidelines of the French Sarcoma Group and the Rare Gynecologic Tumor Group].

Abstract

Uterine adenosarcoma is a very rare malignancy defined as a biphasic tumor composed of both benign epithelial component and a malignant sarcoma component. The stage of the disease is determined by the presence of myometrial invasion and the extent of extra-uterine disease. The most important histopronostic factors are the existence of a sarcomatous overgrowth defined by a sarcomatous contingent occupying more than 25 % of the volume of the tumor (directly correlated to the grade of the disease), the presence of a heterologous and/or a high-grade component. Stage I adenosarcomas without sarcomatous overgrowth have a good prognosis, with an overall 5-year survival of up to 80 %. In localized disease, complete surgical removal is recommended. The role of hormone therapy, chemotherapy and adjuvant radiotherapy is not established. If possible, relapses should be re-treated surgically, with the aim of achieving complete resection. In the advanced inoperable or metastatic setting, hormone therapy is an option for low-grade adenosarcomas with estrogen receptor (ER) and progesterone receptor (PR) overexpression. For high-grade tumors, the standard chemotherapies are doxorubicin-based combinations, although an integrated approach of surgery and medical treatment should also be considered in this setting.

• Authors: Andy Karabajakian, Catherine Genestie, Pierre Meeus, Frédéric Guyon, Carmen Llacer Moscardo, Sabrina Croce, Sophie Taieb, Florence Duffaud, Patricia Pautier, Isabelle Ray-Coquard, Jean-Yves Blay
• Journal: Bulletin du cancer (Bull Cancer) 2023 Jul-Aug Vol. 110 Issue 7-8 Pg. 836-843 ISSN: 1769-6917 [Electronic] France
• Vernacular Title: Adénosarcomes mullériens de l’utérus – référentiels de prise en charge du GSF-GETO/NETSARC+ et du groupe TMRG.
• PMID: 37202293 (Publication Type: English Abstract, Practice Guideline, Journal Article)
• Copyright: Copyright © 2023 Société Française du Cancer. All rights reserved.

Chemical References

• Hormones

Topics

• Female
• Humans
• Genital Neoplasms, Female (therapy)
• Adenosarcoma (surgery)
• Neoplasm Recurrence, Local (therapy)
• Uterine Neoplasms (surgery)
• Hormones