Effect of scaling and root planing with and without minocycline HCl microspheres on periodontal pathogens and clinical outcomes: A randomized clinical trial.

Abstract

BACKGROUND:

This study tests the effects of scaling and root planing (SRP) versus SRP plus minocycline hydrochloride microspheres (SRP+MM) on 11 periodontal pathogens and clinical outcomes in Stage II-IV Grade B periodontitis participants.

METHODS:

Seventy participants were randomized to receive SRP (n = 35) or SRP+MM (n = 35). Saliva and clinical outcomes were collected for both groups at baseline before SRP, 1-month reevaluation, and at 3- and 6-month periodontal recall. MM were delivered to pockets ≥5 mm immediately after SRP and immediately after the 3-month periodontal maintenance in the SRP+MM group. A proprietary saliva test* was utilized to quantitate 11 putative periodontal pathogens. Microorganisms and clinical outcomes were compared between groups using generalized linear mixed-effects models with fixed effects and random effects terms. Mean changes from baseline were compared between groups via group-by-visit interaction tests.

RESULTS:

Significant reduction in Tannerella forsythia, Treponema denticola, Fusobacterium nucleatum, Prevotella intermedia, Parvimonas micra, and Eikenella corrodens were identified at the 1-month reevaluation after SRP+MM. Six months after SRP with a re-application of MM 3 months after SRP, Fusobacterium nucleatum, Prevotella intermedia, Campylobacter rectus, and Eikenella corrodens were significantly reduced. SRP+MM participants had significant clinical outcome reductions in pockets ≥5 mm at the reevaluation, 3- and 6-month periodontal maintenance, and clinical attachment loss gains at the 6-month periodontal maintenance.

CONCLUSION:

MM delivered immediately after SRP and reapplication at 3 months appeared to contribute to improved clinical outcomes and sustained decreased numbers of Fusobacterium nucleatum, Prevotella intermedia, Campylobacter rectus, and Eikenella corrodens at 6 months.

• Authors: Michelle C Arnett, Phonsuda Chanthavisouk, Massimo Costalonga, Christine M Blue, Michael D Evans, Danna R Paulson
• Journal: Journal of periodontology (J Periodontol) Vol. 94 Issue 9 Pg. 1133-1145 (09 2023) ISSN: 1943-3670 [Electronic] United States
• PMID: 37191955 (Publication Type: Randomized Controlled Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2023 American Academy of Periodontology.

Chemical References

• Minocycline
• Anti-Bacterial Agents

Topics

• Humans
• Minocycline (therapeutic use)
• Root Planing
• Microspheres
• Periodontal Pocket
• Dental Scaling
• Fusobacterium nucleatum
• Prevotella intermedia
• Eikenella corrodens
• Follow-Up Studies
• Periodontal Attachment Loss
• Anti-Bacterial Agents (therapeutic use, pharmacology)