[A Case of Primary Signet Ring Cell Carcinoma of the Urinary Bladder Showing Effectiveness of Chemotherapy with Gemcitabine and Cisplatin].

Abstract

A 55-year-old female presented to the hospital with a complaint of gross hematuria. Transurethral resection of bladder tumor was performed. The specimens pathologically showed signet ring cells and no urothelial carcinoma components. Magnetic resonance imaging and computed tomographic (CT) scan revealed bladder tumor, cervical metastasis, bilateral ovarian metastasis, and multiple lymph node metastasis. She was diagnosed with a primary signet ring cell carcinoma of the urinary bladder with cT3bN2M1, and was treated with chemotherapy of gemcitabine and cisplatin combination (GC). After 2 cycles of GC, the value of CEA which was elevated to 106 ng/ml before treatment, became negative. CT scan showed that her disease had successfully responded to the chemotherapy, and remained efficacious till the end of 6 cycles. The patient subsequently received 1 cycle of gemcitabine and nedaplatin and 3 cycles of avelumab due to renal insufficiency. Yet, 14 months after diagnosis, cerebellar metastases appeared and the patient died of meningeal carcinomatosis.

• Authors: Makoto Ishii, Yoshiyuki Yamamoto, Akihiro Yoshimura, Takuji Hayashi, Norihiko Kawamura, Akira Nagahara, Yasutomo Nakai, Masashi Nakayama, Kazuo Nishimura
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 69 Issue 4 Pg. 107-112 (Apr 2023) ISSN: 0018-1994 [Print] Japan
• PMID: 37183041 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Cisplatin
• Gemcitabine

Topics

• Female
• Humans
• Middle Aged
• Cisplatin
• Gemcitabine
• Urinary Bladder
• Urinary Bladder Neoplasms (diagnostic imaging, drug therapy, surgery)
• Carcinoma, Signet Ring Cell (diagnostic imaging, drug therapy, surgery)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)