Numerous research studies have proved that
lactate is pivotal in
tumor proliferation,
metastasis, and recurrence, so disrupting the
lactate metabolism in the tumor microenvironment (TME) has become one of the effective methods of
tumor treatment. Herein, we have developed a versatile nanoparticle (HCLP NP) based on hollow
Prussian blue (HPB) as the functional carrier for loading α-cyano-4-hydroxycinnamate (CHC), and
lactate oxidase (LOD), followed by coating with
polyethylene glycol to enhance chemodynamic
therapy (CDT) and the antimetastatic effect of
cancer. The obtained HCLP NPs would be degraded under endogenous mild acidity within the TME to simultaneously release CHC and LOD. CHC inhibits the expression of monocarboxylate transporter 1 in
tumors, thereby interrupting the uptake of
lactate from the outside and alleviating tumor hypoxia by reducing
lactate aerobic respiration. Meanwhile, the released LOD can catalyze the decomposition of
lactate into
hydrogen peroxide, further enhancing the efficacy of CDT by generating plenty of toxic
reactive oxygen species through the Fenton reaction. The strong absorbance at about 800 nm endows HCLP NPs with excellent photoacoustic imaging properties. Both in vitro and in vivo studies have demonstrated that HCLP NPs can inhibit
tumor growth and
metastasis, providing a new possibility for
tumor therapy.