Anastomotic leakage (AL) after
esophagectomy is the most impactful complication after
esophagectomy. Ischemic conditioning (ISCON) of the stomach >14 days prior to
esophagectomy might reduce the incidence of AL. The current trial was conducted to prospectively investigate the safety and feasibility of laparoscopic ISCON in selected patients. This international multicenter feasibility trial included patients with
esophageal cancer at high risk for AL with major calcifications of the thoracic aorta or a
stenosis in the celiac trunk. Patients underwent laparoscopic ISCON by occlusion of the left gastric and the short gastric arteries followed by
esophagectomy after an interval of 12-18 days. The primary endpoint was complications Clavien-Dindo ≥ grade 2 after ISCON and before
esophagectomy. Between November 2019 and January 2022, 20 patients underwent laparoscopic ISCON followed by
esophagectomy. Out of 20, 16 patients (80%) underwent
neoadjuvant treatment. The median duration of the laparoscopic ISCON procedure was 45 minutes (range: 25-230). None of the patients developed intraoperative or postoperative complications after ISCON.
Hospital stay after ISCON was median 2 days (range: 2-4 days).
Esophagectomy was completed in all patients after a median of 14 days (range: 12-28). AL occurred in three patients (15%), and gastric tube
necrosis occurred in one patient (5%). In hospital, the 30-day and 90-day mortalities were 0%. Laparoscopic ISCON of the gastric conduit is feasible and safe in selected
esophageal cancer patients with an impaired vascular status. Further studies have to prove whether this innovative strategy
aids to reduce the incidence of AL.