Developing sensitive practical sensors for monitoring
pesticide residues in edible foods and environmental samples is vital for food safety and environmental protection.
Enzyme-inhibited biosensors offer effective alternative sensing strategies by using the inherent characteristics of pesticides. To further improve the degradation function of
pesticide sensors, here, a target-triggered
porphyrin metal-organic framework (MOF)-based nanosystem was designed with the synergetic bifunction of sensitive detection and controllable degradation of the
triazophos pesticide. As a result of
triazophos-inhibited
glutathione consumption, the MOF collapsed and released the
ligand porphyrin, leading to the recovery of fluorescence and
photosensitization of the free
porphyrin. The fluorescence recovery resulted in a sensitive detection limit of 0.6 ng mL-1 for
triazophos, which was also applied for the determination of contaminated samples and bioaccumulation in rice. Furthermore, the target-activated photocatalytic ability of
porphyrin endowed the system with the ability to effectively generate
reactive oxygen species for degrading
triazophos with a removal rate of ∼85%, achieving eco-friendly synergetic detection and photodegradation in a controllable way. Therefore, the intelligent multifunctional MOF system demonstrated the potential of programmable systems for jointly controllable tracking and elimination of
pesticide residues in the environment and opened a new avenue for designing a precise mechanism for stimulus-triggered degradation of
pesticide residues accompanied by sensitive detection for environmental friendliness and food safety.