Validity of self-reported migraine in adolescents and children.

Abstract

OBJECTIVE:

To assess agreement for migraine day between self-report and diagnostic guidelines for children and adolescents using a headache diary.

BACKGROUND:

Trial guidelines recommend prospective collection of headache features and adoption of migraine day as an outcome measure, but there is no clear consensus on the definition of migraine day.

METHODS:

This is a secondary analysis of data from two projects-a prospective cohort study validating a pediatric scale of treatment expectancy and a clinical trial of occipital nerve blocks to treat status migrainosus. Participants completed a text message-based diary for 4 or 12 weeks (depending on treatment), and a detailed headache assessment on a random 20% of headache days. Using this assessment, we determined whether a headache day qualified for migraine or probable migraine, based on the International Classification of Headache Disorders, 3rd edition (ICHD-3).

RESULTS:

Of 122 enrolled children and adolescents, 106 (86.9%) completed ≥1 detailed headache assessment (438 entries). We found moderate agreement between self-reported and ICHD-derived migraine day, with a Cohen's Kappa of 0.50 (positive predictive value [PPV]: 0.66; negative predictive value [NPV]: 0.85; correlation: 0.51). Allowing for ICHD-derived probable migraine significantly increased PPV (0.66 vs. 0.94; 95% CI: 0.57-0.74 vs. 0.90-0.97), but decreased NPV (0.85 vs. 0.293; CI: 0.77-0.90 vs. 0.199-0.40), Cohen's Kappa (0.50 vs. 0.237; CI: 0. 389-0.60 vs. 0.139-0.352), and correlation (r = 0.51 vs. 0.302; CI: 0.41-0.61 vs. 0.192-0.41). Pain severity (OR: 5.7; CI: 2.39-13.8), photophobia (OR: 4.1; CI: 1.02-16.6), and phonophobia (OR: 7.5; CI: 1.95-29.3) were significantly associated with participants' perception of migraine.

CONCLUSION:

We found only moderate agreement between self-reported and ICHD-derived migraine day, suggesting both measures are not equal but may represent overlapping aspects of migraine as a disease. This highlights the difficulty of applying ICHD criteria to individual attacks. We recommend greater methodological transparency in future research to avoid readers conflating both measures.

• Authors: Danielle J Kellier, Blanca Marquez de Prado, Dana Haagen, Philip Grabner, Nichelle Raj, Lara Lechtenberg, Gerardo Velasquez, Jesse Y Hsu, John T Farrar, Andrew D Hershey, Christina L Szperka
• Journal: Headache (Headache) Vol. 63 Issue 5 Pg. 634-641 (05 2023) ISSN: 1526-4610 [Electronic] United States
• PMID: 37140013 (Publication Type: Journal Article)
• Copyright: © 2023 American Headache Society.

Topics

• Humans
• Child
• Adolescent
• Self Report
• Prospective Studies
• Migraine Disorders (diagnosis, epidemiology)
• Headache Disorders
• Headache