Reduction of postoperative infection in elective colon surgery with preoperative administration of kanamycin and erythromycin.

Abstract

The results of a randomized prospective preoperative antibiotic study in colon surgery is presented. Antibiotics were given by mouth for 2 days prior to operation: kanamycin (1 gm four times a day) and erythromycin (750 mg three times a day). Kanamycin combined with erythromycin significantly reduced wound infection as compared to kanamycin with a placebo (three of 38 vs. 16 of 39, P less than 0.001). Thus oral aminoglycoside given alone appears to be inadequate to offer protection against postoperative infection in elective colon surgery.

• Authors: S Wapnick, R Guinto, I Reizis, H H LeVeen
• Journal: Surgery (Surgery) Vol. 85 Issue 3 Pg. 317-21 (Mar 1979) ISSN: 0039-6060 [Print] United States
• PMID: 371048 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Placebos
• Kanamycin
• Erythromycin

Topics

• Administration, Oral
• Adult
• Aged
• Clinical Trials as Topic
• Colectomy
• Colostomy
• Double-Blind Method
• Drug Evaluation
• Drug Therapy, Combination
• Erythromycin (administration & dosage, therapeutic use)
• Humans
• Kanamycin (administration & dosage, therapeutic use)
• Middle Aged
• Placebos
• Preoperative Care
• Surgical Wound Infection (prevention & control)