Abstract | OBJECTIVE: METHOD: Male Wistar rats weighing between 250g and 300g were used. Status epilepticus was induced using 385 mg/kg i.p. pilocarpine. After 40 days the thoracic aorta was dissected and divided into 4 mm rings and the vascular smooth muscle reactivity to phenylephrine was evaluated. RESULTS: CONCLUSIONS: Our findings demonstrated for the first time that epilepsy is capable of causing a reduction of vascular reactivity in rat aortas. These results suggest that vascular reactivity reduction is associated with increased production of Nitric Oxide (NO) as an organic attempt to avoid hypertension produced by excessive sympathetic activation.
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Authors | Karolini Zuqui Nunes, Fulvio Alexandre Scorza, Esper Abrão Cavalheiro, Dalton Valentim Vassallo |
Journal | Clinics (Sao Paulo, Brazil)
(Clinics (Sao Paulo))
Vol. 78
Pg. 100195
( 2023)
ISSN: 1980-5322 [Electronic] United States |
PMID | 37099815
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved. |
Chemical References |
- Vasoconstrictor Agents
- NG-Nitroarginine Methyl Ester
- Catalase
- Pilocarpine
- Phenylephrine
- Nitric Oxide
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Topics |
- Rats
- Male
- Animals
- Vasoconstrictor Agents
(pharmacology)
- NG-Nitroarginine Methyl Ester
(pharmacology)
- Rats, Wistar
- Catalase
- Pilocarpine
- Phenylephrine
(pharmacology)
- Aorta, Thoracic
(physiology)
- Status Epilepticus
- Nitric Oxide
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