A Retrospective Real-World Evidence Evaluation of the Characteristics of Exocrine Pancreatic Insufficiency in Patients With Chronic Pancreatitis and Type 2 Diabetes Treated With Pancrelipase in the United States.

Abstract

OBJECTIVES:

This retrospective real-world data analysis assessed clinical/health care professional characteristics of gastrointestinal symptom profiles in pancrelipase-treated patients with exocrine pancreatic insufficiency symptoms and chronic pancreatitis (CP) or type 2 diabetes (T2D).

METHODS:

Data were from the Decision Resources Group Real-World Evidence Data Repository US database. Patients 18 years and older receiving pancrelipase (Zenpep) between index dates August 2015 and June 2020 were included. Gastrointestinal symptoms were assessed 6, 12, and 18 months post-index versus baseline.

RESULTS:

A total of 10,656 pancrelipase-treated patients with CP (n = 3215) or T2D (n = 7441) were identified. Significant/sustained reductions in gastrointestinal symptoms were observed in both cohorts after pancrelipase treatment (P < 0.001) versus baseline. Significantly fewer patients with CP compliant with treatment for more than 270 days (n = 1553) reported abdominal pain (P < 0.001) and nausea/vomiting (P < 0.05) versus those compliant for less than 90 days (n = 1115). Significantly fewer patients with T2D compliant with treatment for more than 270 days (n = 2964) reported abdominal pain (P < 0.001) and diarrhea/steatorrhea (P < 0.05) versus those compliant for less than 90 days (n = 2959).

CONCLUSIONS:

Pancrelipase reduced exocrine pancreatic insufficiency symptoms in patients with CP or T2D, with greater treatment compliance associated with improved gastrointestinal symptom profiles.

• Authors: Jonathan Rosenberg, Manchikanti Nagarjuna Reddy, Prafulla Seelam, Olivia Li, Janine Twal, Jennifer Pack
• Journal: Pancreas (Pancreas) 2022 Nov-Dec 01 Vol. 51 Issue 10 Pg. 1308-1314 ISSN: 1536-4828 [Electronic] United States
• PMID: 37099771 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

Chemical References

• Pancrelipase
• Gastrointestinal Agents

Topics

• Humans
• United States
• Pancrelipase (therapeutic use)
• Gastrointestinal Agents (adverse effects)
• Diabetes Mellitus, Type 2 (complications, drug therapy)
• Retrospective Studies
• Exocrine Pancreatic Insufficiency (drug therapy, etiology)
• Pancreatitis, Chronic (complications, drug therapy, chemically induced)
• Abdominal Pain (etiology, chemically induced)