[Effect of fenibut on cardiac hemodynamics in experimental hypertension from the aspect of age].

Abstract

The effect of phenibut on cardiodynamics in 6-7-week-old rats and 14-16-week-old rats with spontaneous, renal and situational hypertension was studied in a 14-day chronic experiment. Phenibut in doses of 25 (young rats) and 50 (adult rats), mg/kg orally was found to exert the pressor effect in the first week and the hypotensive effect in the second week. In both age groups of rats with situational hypertension phenibut decreased arterial blood pressure.

• Authors: S V Gracheva, G V Kovalev
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1986 Mar-Apr Vol. 49 Issue 2 Pg. 56-9 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie fenibuta na kardiogemodinamiku pri éksperimental'noĭ gipertenzii v vozrastnom aspekte.
• PMID: 3709776 (Publication Type: Comparative Study, Journal Article)

Chemical References

• gamma-Aminobutyric Acid
• 4-amino-3-phenylbutyric acid

Topics

• Aging (drug effects)
• Animals
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Heart (drug effects, physiopathology)
• Hemodynamics (drug effects)
• Hypertension (drug therapy, physiopathology)
• Hypertension, Renal (drug therapy, physiopathology)
• Male
• Rats
• Rats, Inbred SHR
• Stress, Psychological (drug therapy, physiopathology)
• Time Factors
• gamma-Aminobutyric Acid (analogs & derivatives, therapeutic use)