Microwave-Assisted Synthesis, Structure, and Preliminary Biological Evaluation of Novel 6-Methoxy-5,6-dihydro-5-azapurines.

Abstract

We herein disclose the microwave-assisted synthesis of previously unreported 6-methoxy-5,6-dihydro-5-azapurines, whose purine-like scaffold is promising for drug discovery. The method is simple, fast, and relies on easily accessible reagents such as trimethyl orthoformate, acetic acid, and aminotriazole-derived N,N'-disubstituted formamidines. The preliminary biological evaluation revealed that selected representatives of synthesized 6-methoxy-5,6-dihydro-5-azapurines dose-dependently reduce the viability of HepG2 and A549 cancer cells having little to no influence on five tested purinergic receptors.

• Authors: Alena I Siutkina, Svetlana Kalinina, Rongfang Liu, Laura H Heitman, Anna Junker, Constantin G Daniliuc, Dmitrii V Kalinin
• Journal: ACS omega (ACS Omega) Vol. 8 Issue 15 Pg. 14097-14112 (Apr 18 2023) ISSN: 2470-1343 [Electronic] United States
• PMID: 37091407 (Publication Type: Journal Article)
• Copyright: © 2023 The Authors. Published by American Chemical Society.