Significant limitations of the reactive medical approach in
breast cancer management are clearly reflected by alarming statistics recorded worldwide. According to the WHO updates, breast
malignancies become the leading
cancer type. Further, the portion of premenopausal
breast cancer cases is permanently increasing and demonstrates particularly aggressive patterns and poor outcomes exemplified by young patients with
triple-negative breast cancer that lacks targeted
therapy. Accumulating studies suggest the crucial role of stem cells in tumour biology, high metastatic activity, and
therapy resistance of aggressive
breast cancer. Therefore, targeting
breast cancer stem cells is a promising treatment approach in secondary and tertiary
breast cancer care. To this end, naturally occurring substances demonstrate high potential to target cancer stem cells which, however, require in-depth analysis to identify effective anti-
cancer agents for cost-effective
breast cancer management. The current article highlights the properties of
flavonoids particularly relevant for targeting
breast cancer stem cells to mitigate
therapy resistance. The proposed approach is conformed with the principles of 3P medicine by applying predictive diagnostics, patient stratification and treatments tailored to the individualised patient profile. Expected impacts are very high, namely, to overcome limitations of reactive medical services improving individual outcomes and the healthcare economy in
breast cancer management. Relevant clinical applications are exemplified in the paper.