Association Between Low-Density Lipoprotein-Cholesterol Level and Risk of Intracranial Atherosclerotic Stenosis: Results From the APAC Study.

Abstract

BACKGROUND:

It is unknown whether plasma low-density lipoprotein-cholesterol level (LDL-C) can predict the occurrence of intracranial atherosclerotic stenosis (ICAS), especially asymptomatic (A)ICAS. This study investigated whether LDL-C level is independently associated with AICAS.

METHODS:

The Asymptomatic Polyvascular Abnormalities Community study is an ongoing community-based, prospective, long-term follow-up observational study with 3387 participants. AICAS was diagnosed by transcranial Doppler ultrasonography. The participants were divided into 3 groups based on LDL-C level. Cox regression was used to evaluate the association between LDL-C level and incidence of AICAS.

RESULTS:

During 2 years of follow-up, 9.98% of participants were diagnosed with AICAS. The incidence of AICAS (person-years with 95% CI) was 4.99% (4.48%-5.50%). AICAS incidence did not increase with increasing LDL-C level. Compared with the <2.6 mmol/l subgroup, the incidence of asymptomatic ICAS was not significantly higher in the 2.6 to 3.4 and >3.4 mmol/l subgroups after adjusting for confounding factors (hazard ratio=0.95, 95% CI: 0.86-1.03 and hazard ratio=0.96, 95% CI: 0.84-1.10, respectively).

CONCLUSIONS:

LDL-C is not an independent predictor of AICAS incidence in the Chinese population.

• Authors: Yuan Shen, Jing Wang, Anxin Wang, Xingquan Zhao
• Journal: The neurologist (Neurologist) Vol. 28 Issue 5 Pg. 300-303 (Sep 01 2023) ISSN: 2331-2637 [Electronic] United States
• PMID: 37083844 (Publication Type: Observational Study, Journal Article)
• Copyright: Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

Chemical References

• Cholesterol, LDL

Topics

• Humans
• Risk Factors
• Constriction, Pathologic (diagnostic imaging, epidemiology)
• Prospective Studies
• Cholesterol, LDL
• Intracranial Arteriosclerosis (diagnostic imaging, epidemiology)