The protective effects of vitamin E on microcephaly in rats X-irradiated in utero: DNA, lipid peroxide and confronting cisternae.

Abstract

Fetuses from rats given either water or 0.03% D,L-alpha-tocopherol acetate (vitamin E) as a drinking fluid and X-irradiated with 100 rad on gestational day 13 were examined on gestational day 21. Mean cerebral weight which was significantly reduced by the X-irradiation was increased by vitamin E supplementation but the level did not reach that in sham-irradiated controls. Administration of vitamin E caused an increase in DNA concentration which was significantly reduced by X-irradiation with water treatment. An increase in the mean level of lipid peroxide formation was observed in the water-treated, X-irradiated group in the sample at zero time but not in the vitamin E-treated, X-irradiated group. In the cytoplasm of fetal cerebral neurons from X-irradiated dams with vitamin E supplementation, confronting cisternae were frequently observed between two nuclear envelopes. Confronting cisternae may be considered as a repair mechanism of vitamin E against X-irradiated neuronal damage in the fetal cerebrum. This study provides evidence of the protection by vitamin E of neuronal development in X-irradiated fetuses, through its antioxidant properties, against attacks by free radicals and/or lipid peroxide.

• Authors: H Tanaka, S Iwasaki, K Inomata, F Nasu, S Nishimura
• Journal: Brain research (Brain Res) Vol. 392 Issue 1-2 Pg. 11-7 (Jun 1986) ISSN: 0006-8993 [Print] Netherlands
• PMID: 3708371 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lipid Peroxides
• Vitamin E
• DNA

Topics

• Abnormalities, Radiation-Induced (metabolism, prevention & control)
• Animals
• Brain Chemistry
• DNA (analysis)
• Female
• Lipid Peroxides (analysis)
• Microcephaly (metabolism, prevention & control)
• Organ Size
• Pregnancy
• Rats
• Rats, Inbred Strains
• Vitamin E (therapeutic use)