METHODS: In the LOOP Study (
Atrial Fibrillation Detected by Continuous ECG Monitoring Using Implantable Loop Recorder to Prevent
Stroke in High-Risk Individuals), 6004 AF-naïve individuals at least 70 years old and with additional
stroke risk factors were randomized 1:3 to either screening with an implantable loop recorder (ILR) and initiation of anticoagulation upon detection of AF episodes lasting ≥6 minutes or usual care (control). This post hoc analysis included study participants with available
NT-proBNP measurement at baseline.
RESULTS: A total of 5819 participants (96.9% of the trial population) were included. The mean age was 74.7 years (SD, 4.1 years) and 47.5% were female. The median
NT-proBNP level was 15 pmol/L (interquartile range, 9-28 pmol/L) corresponding to 125 pg/mL (interquartile range, 76-233 pg/mL).
NT-proBNP above median was associated with an increased risk of AF diagnosis both in the ILR group (hazard ratio, 1.84 [95% CI, 1.51-2.25]) and the control group (hazard ratio, 2.79 [95% CI, 2.30-3.40]). Participants with
NT-proBNP above the median were also at higher risk of clinical events compared with those having lower levels (hazard ratio, 1.21 [95% CI, 0.96-1.54] for
stroke or systemic
embolism [SE], 1.60 [95% CI, 1.32-1.95] for
stroke/SE/cardiovascular death, and 1.91 [95% CI, 1.61-2.26] for all-cause death). Compared with usual care, ILR screening was associated with significant reductions in
stroke/SE and
stroke/SE/cardiovascular death among participants with
NT-proBNP above median (hazard ratio, 0.60 [95% CI, 0.40-0.90] and 0.70 [95% CI, 0.53-0.94], respectively) but not among those with lower levels (Pinteraction=0.029 for
stroke/SE and 0.045 for
stroke/SE/cardiovascular death). No risk reduction in all-cause death was observed in either
NT-proBNP subgroup for ILR versus control (Pinteraction=0.68). Analyzing
NT-proBNP as a continuous variable yielded similar findings.
CONCLUSIONS: In an older population with additional
stroke risk factors, ILR screening for AF was associated with a significant reduction in
stroke risk among individuals with higher
NT-proBNP levels but not among those with lower levels. These findings should be considered hypothesis generating and warrant further study before clinical implementation.
REGISTRATION: URL: https://www.
CLINICALTRIALS: gov; Unique identifier: NCT02036450.