Abstract | INTRODUCTION: Restoration of podocyte autophagy is considered as a feasible strategy for the treatment of diabetic kidney disease (DKD). This study aimed at investigating the protective effect and potential mechanism of vitamin D on podocyte injury of DKD. METHODS: RESULTS:
Albuminuria in a db/db mouse model was markedly attenuated after treatment with paricalcitol. This was accompanied by alleviation of mesangial matrix expansion and podocyte injury. Besides, the impaired autophagy in podocytes under diabetic conditions was also markedly enhanced after paricalcitol or calcitriol treatment, accompanied by restored decreased podocyte slit diaphragm proteins podocin and nephrin. Furthermore, the protective effect of calcitriol against HG-induced podocyte apoptosis could be abated by autophagy inhibitor 3-methyladenine. CONCLUSION:
Vitamin D ameliorates podocyte injury of DKD by enhancing podocyte autophagy activity, which may become a potential candidate autophagy activator for the therapeutic interventions for DKD.
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Authors | Xiaoyi Zhang, Li Zhang, Yingzhen Wen, Mengxian Zhang, Shuangxin Liu, Houqin Xiao |
Journal | Kidney & blood pressure research
(Kidney Blood Press Res)
Vol. 48
Issue 1
Pg. 314-325
( 2023)
ISSN: 1423-0143 [Electronic] Switzerland |
PMID | 37054686
(Publication Type: Journal Article)
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Copyright | © 2023 The Author(s). Published by S. Karger AG, Basel. |
Chemical References |
- Vitamin D
- Calcitriol
- Vitamins
|
Topics |
- Mice
- Animals
- Diabetic Nephropathies
(pathology)
- Podocytes
(metabolism)
- Vitamin D
(pharmacology, therapeutic use, metabolism)
- Calcitriol
(pharmacology, therapeutic use, metabolism)
- Diabetes Mellitus, Experimental
(complications)
- Vitamins
(pharmacology, therapeutic use, metabolism)
- Autophagy
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