Role of T-box transcription factor 3 in gastric cancers.

Abstract

The expression of T-box transcription factor 3 (TBX3) has been identified in various cancers, including gastric cancers. Its role in breast cancers and melanomas has been intensively studied, and its contribution to the progression of cancers through suppressing senescence and promoting epithelial-mesenchymal transition has been reported. Recent reports on the role of TBX3 in gastric cancers have implied its involvement in gastric carcinogenesis. Considering its pivotal role in the initiation and progression of cancers, TBX3 could be a promising therapeutic target for gastric cancers.

• Authors: Naoki Asano, Akira Imatani, Akio Takeuchi, Masashi Saito, Xiao-Yi Jin, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune
• Journal: World journal of gastrointestinal pathophysiology (World J Gastrointest Pathophysiol) Vol. 14 Issue 2 Pg. 12-20 (Mar 22 2023) ISSN: 2150-5330 [Print] United States
• PMID: 37035275 (Publication Type: Journal Article, Review)
• Copyright: ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.