A multistrain probiotic increases the serum glutamine/glutamate ratio in patients with cirrhosis: a metabolomic analysis.

Abstract

To explore the potential mechanisms underlying the effects of a probiotic in cirrhotic patients, we analyzed the blood metabolome using proton nuclear magnetic resonance (1H-NMR) spectroscopy in 32 patients with cirrhosis and cognitive dysfunction or falls. Patients were randomized to receive a multistrain probiotic or placebo for 12 weeks. Among the 54 metabolites identified, the only significant changes in the probiotic group were an increase in glutamine, a decrease in glutamate, and an increase in the glutamine/glutamate ratio. In the placebo group, glutamate increased and the glutamine/glutamate ratio decreased. Our results suggest the multistrain probiotic could influence glutamine/glutamate metabolism, increasing the capacity of ammonia detoxification.

• Authors: Luca Laghi, Eva Román, Qiuyu Lan, Juan Camilo Nieto, Aleix Canalda-Baltrons, Maria Poca, Maria B Sánchez-Rodríguez, Joan Clària, Edilmar Alvarado, Berta Cuyàs, Elisabet Sánchez, Sílvia Vidal, Carlos Guarner, Àngels Escorsell, Chaysavanh Manichanh, German Soriano
• Journal: Hepatology communications (Hepatol Commun) Vol. 7 Issue 4 (04 01 2023) ISSN: 2471-254X [Electronic] United States
• PMID: 37026745 (Publication Type: Randomized Controlled Trial, Letter, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.

Chemical References

• Glutamine
• Glutamic Acid

Topics

• Humans
• Glutamine (metabolism)
• Glutamic Acid (metabolism)
• Metabolomics (methods)
• Liver Cirrhosis
• Probiotics (therapeutic use)