Exogenous Ochronosis With Ocular Involvement From Chronic Use of Teavigo.

Abstract

Exogenous ochronosis refers to accumulation of homogentisic acid metabolites in tissues, manifesting as pigmentation of affected tissues. Phenolic compounds are most commonly implicated, including hydroquinone, quinine, phenol, resorcinol, mercury, and picric acid. The affected connective tissues exhibit brownish discoloration when heavily pigmented and the histopathological appearance is characteristic with "banana-shaped" ochre-colored pigment deposits. Herein, the authors describe a rare case of exogenous ochronosis involving the conjunctiva, sclera and skin, as a result of chronic use of Teavigo (94% epigallocatechin gallate), a polyphenol compound with postulated antioxidant and antiapoptotic activity.

• Authors: Vijitha S Vempuluru, Andrea Laiton, Tatyana Milman, Jason B Lee, Ralph C Eagle Jr, Carol L Shields
• Journal: Ophthalmic plastic and reconstructive surgery (Ophthalmic Plast Reconstr Surg) 2023 Sep-Oct 01 Vol. 39 Issue 5 Pg. e139-e142 ISSN: 1537-2677 [Electronic] United States
• PMID: 37010051 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2023 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.

Topics

• Humans
• Ochronosis (chemically induced, diagnosis, pathology)
• Alkaptonuria (pathology)
• Skin (pathology)
• Pigmentation Disorders