Beta-blockers are widely used in the treatment of
hypertension,
heart failure and
ischemic heart disease. However, unstandardized medication results in diverse clinical outcomes in patients. The main causes are unattained optimal doses, insufficient follow-up and patients' poor adherence. To improve the medication inadequacy, our team developed a novel therapeutic
vaccine targeting β1-adrenergic receptor (β1-AR). The β1-AR
vaccine named ABRQβ-006 was prepared by chemical conjugation of a screened β1-AR
peptide with Qβ virus like particle (VLP). The
antihypertensive, anti-remodeling and cardio-protective effects of β1-AR
vaccine were evaluated in different animal models. The ABRQβ-006
vaccine was immunogenic that induced high titers of
antibodies against β1-AR
epitope peptide. In the
NG-nitro-L-arginine methyl ester (
L-NAME) + Sprague Dawley (SD)
hypertension model, ABRQβ-006 lowered systolic blood pressure about 10 mmHg and attenuated
vascular remodeling, myocardial
hypertrophy and perivascular
fibrosis. In the pressure-overload transverse aortic constriction (TAC) model, ABRQβ-006 significantly improved cardiac function, decreased myocardial
hypertrophy, perivascular
fibrosis and
vascular remodeling. In the
myocardial infarction (MI) model, ABRQβ-006 effectively improved cardiac remodeling, reduced cardiac
fibrosis and inflammatory infiltration, which was superior to
metoprolol. Moreover, no significant immune-mediated damage was observed in immunized animals. The ABRQβ-006
vaccine targeting β1-AR showed the effects on
hypertension and heart rate control, myocardial remodeling inhibition and cardiac function protection. These effects could be differentiated in different types of diseases with diverse pathogenesis. ABRQβ-006 could be a novel and promising method for the treatment of
hypertension and
heart failure with different etiologies.