Effectiveness of bronchial thermoplasty in patients with asthma exhibiting overweight/obesity and low quality of life.

Abstract

Bronchial thermoplasty (BT) is effective in some severe asthma patients; however, the specific asthma phenotypes that produce a good response to BT are not fully understood. Clinical data were retrospectively reviewed in severe asthma patients who underwent BT at a single institution in Japan. At the follow-up assessment, the Asthma Quality of Life Questionnaire (AQLQ) scores (P = 0.003), maintenance oral corticosteroid doses (P = 0.027), and exacerbation frequency (P = 0.017) were significantly improved, while prebronchodilator-forced expiratory volume in 1 second (% predicted) did not significantly change (P = 0.19). When we grouped the patients into 2 groups according to their body mass index levels, the AQLQ scores were more improved in patients with overweight/obesity than those with normal weight (P = 0.01). This study showed that patients with non-controlled severe asthma exhibiting overweight/obesity and low quality of life had potential benefits from BT.

• Authors: Kenta Nishi, Chie Yoshimura, Kyohei Morita, Ryoichi Ishikawa, Erika Toyokura, Tadao Nagasaki, Hisako Matsumoto, Yasuo Nishizaka
• Journal: The World Allergy Organization journal (World Allergy Organ J) Vol. 16 Issue 3 Pg. 100756 (Mar 2023) ISSN: 1939-4551 [Print] United States
• PMID: 36994444 (Publication Type: Journal Article)
• Copyright: © 2023 The Author(s).