Epidermal growth factor receptor (EGFR) mutations have been frequently detected in patients with pulmonary
adenocarcinoma. EGFR Exon 19Del and 21L858R mutations are the two most common EGFR mutations. EGFR-
tyrosine kinase inhibitors (TKIs) are widely employed to treat patients with
non-small cell lung cancer (NSCLC) harboring EGFR mutations. Recently, there has been rapid growth in clinical trials assessing neoadjuvant targeted
therapy, indicating good application prospects owing to high efficiency and low toxicity. Herein, we discuss the case of a 56-year-old male patient who was initially diagnosed with stage IIIA pulmonary
adenocarcinoma (AJCC,8th edition) of the left lower lung with an EGFR Exon 19Del mutation. The patient was treated with
osimertinib but failed to undergo timely review and surgery. Subsequently, the patient underwent two cycles of
neoadjuvant chemotherapy (NAC) combined with neoadjuvant targeted
therapy. After the
tumor load and size had significantly decreased, radical surgery was successfully performed under thoracoscopy. However, postoperative pathology revealed
carcinosarcoma, pT2aN0M0, stage IB, and the pathological response was 50%. The present case report provides practical clinical evidence for the application of neoadjuvant targeted
therapy combined with
chemotherapy for locally advanced primary pulmonary
carcinosarcoma with EGFR mutation.