The cut-off value for HOMA-IR discriminating the insulin resistance based on the SHBG level in women with polycystic ovary syndrome.

Abstract

Introduction:

The study aimed to estimate the cut-off value for homeostatic model assessment for insulin resistance (HOMA-IR) discriminating the insulin resistance based on the sex hormones binding globulin (SHBG) level in women with polycystic ovary syndrome (PCOS).

Materials and methods:

Data from medical records of 854 Caucasian women diagnosed with PCOS were analyzed. Anthropometric data, fasting plasma glucose, insulin and SHBG levels were measured. HOMA-IR was calculated with a standard formula. The cut-off value was calculated using receiver-operating characteristics.

Results:

Circulating SHBG levels below the normal range (26.1 nmol/L) were found in 25.4% of study participants. This subgroup had a significantly higher BMI, fasting glucose and insulin concentrations and HOMA-IR values. Empirical optimal cut-off values for HOMA-IR corresponding to low SHBG levels was ≥2.1 [area under the curve (AUC) 0.73, accuracy 0.65, sensitivity 72.3%, specificity 63.1%, positive predictive value (PPV) 40.0%, negative predictive value (NPV) 87.0%].

Conclusions:

Our study suggests that the cut-off point for HOMA-IR discriminating the insulin resistance based on the SHBG level, in young Caucasian women with polycystic ovary syndrome is 2.1, and is consistent with the cut-off value adopted by the European Group for the Study of Insulin Resistance (above 2.0).

• Authors: Aleksandra Biernacka-Bartnik, Piotr Kocełak, Aleksander Jerzy Owczarek, Piotr Stanisław Choręza, Leszek Markuszewski, Paweł Madej, Monika Puzianowska-Kuźnicka, Jerzy Chudek, Magdalena Olszanecka-Glinianowicz
• Journal: Frontiers in medicine (Front Med (Lausanne)) Vol. 10 Pg. 1100547 ( 2023) ISSN: 2296-858X [Print] Switzerland
• PMID: 36968815 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 Biernacka-Bartnik, Kocełak, Owczarek, Choręza, Markuszewski, Madej, Puzianowska-Kuźnicka, Chudek and Olszanecka-Glinianowicz.