Abstract | BACKGROUND: CASE PRESENTATION: A 33-year-old male with a history of kidney transplantation was admitted to hospital because of postural epigastric pain. The recipient was CMV seropositive prior to transplantation and received trimethoprim-sulfamethoxazole without universal prophylaxis. Approximately 5 months after renal transplant, the recipient complained postural epigastric pain. An endoscopy revealed diffuse ulcerative lesions in the lower body and in the antrum of the stomach, as well as several erythematous mucosal lesions in the duodenum. Histopathologic examination identified CMV inclusions consistent with invasive CMV disease and immunohistochemical staining showed positive results for HHV-8 and CMV. No tumorous diseases such as Kaposi's sarcoma were detected. After 3 weeks of intravenous ganciclovir treatment, we observed that serum CMV PCR remained within the normal range and clinical symptoms improved. A follow-up endoscopy performed 3 weeks later showed that the severity of the above mentioned lesions had improved. CONCLUSIONS:
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Authors | Sik Lee, Kyoung Min Kim, Hong Pil Hwang, Jeong-Hwan Hwang |
Journal | BMC nephrology
(BMC Nephrol)
Vol. 24
Issue 1
Pg. 69
(03 24 2023)
ISSN: 1471-2369 [Electronic] England |
PMID | 36964509
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2023. The Author(s). |
Chemical References |
- Ganciclovir
- Antiviral Agents
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Topics |
- Male
- Humans
- Adult
- Cytomegalovirus
- Kidney Transplantation
(adverse effects)
- Herpesvirus 8, Human
- Stomach Ulcer
(etiology, complications)
- Duodenitis
(etiology, complications)
- Coinfection
(complications, drug therapy)
- Cytomegalovirus Infections
(complications, diagnosis, drug therapy)
- Ganciclovir
(therapeutic use)
- Pain
(drug therapy)
- Antiviral Agents
(therapeutic use)
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