The complicated
wound repair process caused by microbial
infection is still a clinical problem due to antibiotic resistance. Therefore it is necessary to employ the incorporating bioactive molecules in the dressing to solve this problem. Herein, a multifunctional
nanocomposite hydrogel (CS-HCA-Icps) with the pathological pH-responsive drug release has been developed to promote the
infection-impaired wound healing. CS-HCA-Icps
nanocomposite hydrogel composed of
catechol-grafted
chitosan (CS-HCA) and a
curcumin-Fe3+ coordination nanoparticles (Icps, Cur-Fe3+) exhibits the favorable activities in
free radical scavenging, anti-bacterial and anti-inflammatory. The favorable biocompatibility is also demonstrated both in vitro and in vivo experiments. These demonstrate the promoting efficacy of
hydrogel in wound healing. In this study,
Chitosan (CS) shows excellent biocompatibility and antibacterial properties for tissue repair. After functional modification with HCA, the
catechol groups are beneficial to improve
antioxidant capacity for
wound repair, Moreover, Icps nanomedicine are able to enhance the loaded Cur release in response to the pathological acidic microenvironment at the inflammatory stage of
wounds. Thus, the pathological pH-responsive
hydrogel integrating anti-bacterial,
antioxidant, and anti-inflammatory functions may represent a promising strategy for safe and efficient wound healing, in particular for potential clinical use.