Abstract | BACKGROUND:
Malignant glioma is among the most lethal and frequently occurring brain tumors, and the average survival period is 15 months. Existing chemotherapy has low tolerance and low blood-brain barrier (BBB) permeability; therefore, the required drug dose cannot be accurately delivered to the tumor site, resulting in an insufficient drug effect. METHODS: RESULTS: When the upper part of a mouse brain was irradiated using a laser (0.2 W cm- 2) after transplantation of glioma and injection of ZnPcS, tumor growth was inhibited by approximately 83.6%, and the 50% survival rate of the treatment group increased by 14 days compared to the control group. In glioma with knockout SPARC, the amount of ZnPcS entering the glioma was reduced by 63.1%, indicating that it can target glioma through the SPARC pathway. CONCLUSION:
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Authors | Xingshu Li, Jae Sang Oh, Yoonji Lee, Eun Chae Lee, Mengyao Yang, Nahyun Kwon, Tae Won Ha, Dong-Yong Hong, Yena Song, Hyun Kyu Kim, Byung Hoo Song, Sun Choi, Man Ryul Lee, Juyoung Yoon |
Journal | Biomaterials research
(Biomater Res)
Vol. 27
Issue 1
Pg. 23
(Mar 21 2023)
ISSN: 1226-4601 [Print] England |
PMID | 36945032
(Publication Type: Journal Article)
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Copyright | © 2023. The Author(s). |