An evaluation of fedratinib for adult patients with newly diagnosed and previously treated myelofibrosis.

Abstract

INTRODUCTION:

Myelofibrosis (MF) is a life-shortening myeloproliferative neoplasm that has multiple features such as clonal proliferation, fibrosis and splenomegaly. Until recently, ruxolitinib, a Janus Kinase (JAK) 1/2 inhibitor was the only targeted therapy approved for transplant-ineligible patients with MF and who require treatment for symptoms and/or splenomegaly. However, the discontinuation rate with ruxolitinib at 3 to 5 years is high and mostly due to loss of response or toxicity, and these patients had no subsequent treatment.

AREAS COVERED:

Fedratinib, a selective JAK2 inhibitor, was approved by the Food and Drug Administration (FDA) in August 2019 for the treatment of intermediate-2 or high-risk primary or secondary MF, regardless of prior JAK inhibitor treatment for the management of symptoms and splenomegaly. We discuss herein the development of fedratinib and its pharmacology and pharmacokinetics as well as the clinical development and the future directions. We used PubMed for the search of articles related to fedratinib and myelofibrosis.

EXPERT OPINION:

Fedratinib provided a second-line treatment for patients with MF who failed or discontinued ruxolitinib. New combinations of JAK inhibitors with other targeted therapies are a must in order to improve the management of MF.

• Authors: Khalil Saleh, Vincent Ribrag
• Journal: Expert review of hematology (Expert Rev Hematol) Vol. 16 Issue 4 Pg. 227-236 (04 2023) ISSN: 1747-4094 [Electronic] England
• PMID: 36939633 (Publication Type: Journal Article)

Chemical References

• Janus Kinase 2
• Janus Kinase Inhibitors
• Protein Kinase Inhibitors
• Pyrrolidines
• ruxolitinib
• fedratinib

Topics

• Adult
• Humans
• Janus Kinase 2 (genetics)
• Janus Kinase Inhibitors (therapeutic use)
• Primary Myelofibrosis (diagnosis, drug therapy)
• Protein Kinase Inhibitors (adverse effects)
• Pyrrolidines (therapeutic use)
• Splenomegaly (drug therapy, etiology)