Abstract | BACKGROUND: METHODS: This study recruited 149 PD patients and 84 Age- and sex-matched individuals. According to the Pittsburgh Sleep Quality Index (PSQI) score, PD patients were divided into three groups, good (≤5), intermediate (6-10), and poor (>10). Multivariate logistic regression and receiver operating characteristic (ROC) curve analyses were also performed to identify clinical features and serum UA levels that help establish an accurate diagnostic model for poor sleep quality in PD patients. RESULTS: PD patients who experienced poor sleep quality had lower serum UA levels. PSQI scores have significant negative relationships with serum UA levels and significant positive relationships with Hamilton Depression Scale (HAMD) scores in PD. Poor sleep quality was independently associated with serum UA levels and HAMD scores. A serum UA level of 328.7 μmol/L and HAMD scores of 19.5 could distinguish PD patients with poor or intermediate sleep to a certain extent, sensitivity of 79.4% and specificity of 76.6%. CONCLUSIONS: Low serum UA levels may correlate with the severity of sleep disorder in PD patients and may serve as a biomarker for poor sleep quality in PD.
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Authors | Chuanbin Zhou, Meijuan Gu, Lei Yin, Weifang Yin, Jie Liu, Yongyun Zhu, Kangfu Yin, Chunyan Lei, Zhong Xu, Xinglong Yang |
Journal | Sleep medicine
(Sleep Med)
Vol. 105
Pg. 9-13
(05 2023)
ISSN: 1878-5506 [Electronic] Netherlands |
PMID | 36934617
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2023 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Humans
- Parkinson Disease
(complications, diagnosis)
- Uric Acid
- Sleep Quality
- Sleep Wake Disorders
(etiology)
- Biomarkers
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