Hepatic arterial infusion chemotherapy for patients with hepatocellular carcinoma: Applicability in Western countries.

Abstract

Hepatic arterial infusion chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX-HAIC) has shown a strong anti-tumor effect in hepatocellular carcinoma in China. Different from hepatocellular carcinoma in China, hepatocellular carcinoma in Western countries is caused by hepatitis C and alcoholic liver disease, and is often diagnosed at an early stage, when the tumor is small or the thrombus is not serious. Although there are no reports of FOLFOX-HAIC efficacy for hepatocellular carcinoma in Western countries, FOLFOX-HAIC can be used in patients with large tumors (> 5 cm) (or T3 by TNM stage), and rich blood supply.

• Authors: MinKe He, ShuYue Liu, ZhiCheng Lai, ZeFeng Du, QiJiong Li, Li Xu, Anna Kan, JianXian Shen, Ming Shi
• Journal: Current opinion in pharmacology (Curr Opin Pharmacol) Vol. 70 Pg. 102362 (06 2023) ISSN: 1471-4973 [Electronic] England
• PMID: 36931163 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2023 Elsevier Ltd. All rights reserved.

Chemical References

• Fluorouracil

Topics

• Humans
• Carcinoma, Hepatocellular (drug therapy, pathology)
• Liver Neoplasms (drug therapy, pathology)
• Treatment Outcome
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Fluorouracil (therapeutic use)