Abstract | BACKGROUND: The goal was to investigate the inhibitory effect of formononetin, an active component in Astragalus membranaceus, on the pathogenesis and development of esophageal cancer and the mechanism of action. METHODS: RESULTS: The expression level of COX-2 mRNA in esophageal cancer tissue was significantly higher than that in paracancerous tissue. In the mouse cancer model, the incidence of esophageal cancer in mice in the formononetin treatment group was significantly reduced at week 18 (0/15 vs. 2/15) and at week 24 (6/15 vs. 13/15) (all p < 0.05). Formononetin significantly inhibited the proliferation ability of KYSE170 and KYSE150 cells and inhibited the protein expression of COX-2 and cyclin D1 (both p < 0.05). CONCLUSIONS:
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Authors | Li Chen, Dong Xing, Li-Ru Guo, Jing Jin, Shengmian Li |
Journal | Clinical laboratory
(Clin Lab)
Vol. 69
Issue 3
(Mar 01 2023)
ISSN: 1433-6510 [Print] Germany |
PMID | 36912303
(Publication Type: Journal Article)
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Chemical References |
- formononetin
- Cyclooxygenase 2
- Cyclin D1
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Topics |
- Humans
- Animals
- Mice
- Astragalus propinquus
- Cyclooxygenase 2
(pharmacology)
- Cell Proliferation
- Cyclin D1
(genetics, pharmacology)
- Mice, Inbred C57BL
- Cell Line, Tumor
- Esophageal Neoplasms
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